Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

336  The University of Texas Rio Grande Valley  (84632)

Principal Investigator: Salloum, Ihsan

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 1,760,624

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 5/1/20 - 8/15/22

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Neuroscience

Title of Contract, Award, or Gift: Stem Cell Therapy, Inflammation and Treatment Response in Alcoholism-Depression Comorbidity

Name of Granting or Contracting Agency/Entity: National Institutes of Health (NIH)

Program Title: N/A
CFDA Linked: Alcohol Research Programs


The primary objectives of this study included the following: * To determine the efficacy of allo-hMSCs in reducing inflammation in subjects with AUD-MD with a presence of high inflammatory markers (hsCRP >2mg/L). * To determine whether the effects of a reduction in CRP and other inflammatory markers associated with ahMSC therapy will precede and predict improvement of alcohol use and of depression as indexed by clinician ratings (TLFB and MADRS). * To examine the direct (reduction in CRP and other inflammatory biomarkers) and indirect (reduction in alcohol use and depression) effects of ahMSC therapy on secondary study outcomes including craving, cognition, functioning, quality of life, and other alcohol and depression-related outcomes. * To examine childhood trauma experience as mediators or moderators of the effect of allo-hMSCs on inflammation and on alcohol and depression outcomes.

Discussion: No discussion notes


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