Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

317  The University of Texas Rio Grande Valley  (84613)

Principal Investigator: Maestre, Gladys

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 2,906,000

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 9/30/20 - 8/31/24

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Neuroscience

Title of Contract, Award, or Gift: Integration of Socio-Spatial Data for Neighborhoods with Multi-omic profiles to Identify and Mitigate Factors Affecting Risk of Alzheimer's Disease

Name of Granting or Contracting Agency/Entity: National Institutes of Health (NIH)

Program Title: NIA Behavioral and Social Research LEaders in Alzheimer’s Disease and Its Related Dementias (NIA BSR LEADR) (DP1 -Clinical Trial Not Allowed)
CFDA Linked: Aging Research


Alzheimer´s disease (AD) disproportionately impacts Hispanics/Latinos residing in the US, but the reasons are unknown. The physical and social features of living environments – the neighborhood or el barrio for Mexican Americans – likely influence the relationship between the aging process and individuals' cognitive trajectories but dissecting such contextual vs. individual effects upon risk of Alzheimer´s disease (AD) is a complex problem. To overcome this knowledge gap, this project aims to determine the effects of neighborhood on AD-like cognitive trajectories in Mexican Americans, by a novel approach that integrates 1) individual differences revealed by high-dimensional -omics data and 2) mediation by family and el barrio dynamics; together yielding new evidence to assist neighborhood and city planners and policymakers to improve outcomes in this fastest-growing elderly population in the U.S. SAMs 1.1.1

Discussion: No discussion notes


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