Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

178  University of North Texas  (84474)

Principal Investigator: Wang,Hong

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 490,000

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: - 8/31/23

Restricted Research: YES

Academic Discipline: Chemistry

Department, Center, School, or Institute: College of Science

Title of Contract, Award, or Gift: Cooperative Enamine-Hard Metal Lewis Acid Catalysis for New Asymmetric Organic Transformations

Name of Granting or Contracting Agency/Entity: National Science Foundation

Program Title: N/A
CFDA Linked: Mathematical and Physical Sciences


1.1.1 (SAM); The proposal describes the development of novel catalytic systems for asymmetric organic transformations with particular focus on developing strategies to combine enamine catalysis with hard metal Lewis acid catalysis. The ultimate goal of this project is to develop new carbon-carbon and carbonheteroatom bond-forming reactions that cannot be achieved through organocatalysis or metal catalysis independently. There are three major research objectives of this proposal. First, we will introduce and develop a new strategy, termed as "reversed soft-hard" strategy. This new strategy is expected to provide convenient and versatile tools to facilitate exploration and discovery in cooperative enamine-hard metal Lewis acid catalysis. Second, we will develop novel classes of chiral bimetallic Lewis acid catalysts, which will serve as a complementary approach to the "reversed soft-hard" strategy to introduce asymmetry to the developed reactions. In addition, these chiral bimetallic Lewis acid catalysts will expand the tool box for chiral metal catalysis. Last, we will design and develop a number of [3+2] and [4+3] cycloaddition reactions through cooperative enamine-hard metal Lewis acid catalysis. The purpose is to create new entries to access 5- and 7-membered heterocycles which are currently inaccessible.

Discussion: No discussion notes


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