Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

146  University of North Texas  (84442)

Principal Investigator: Verbeck IV,Guido Fridolin

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 90,087

Exceeds $250,000 (Is it flagged?): No

Start and End Dates: - 10/31/20

Restricted Research: YES

Academic Discipline: Chemistry

Department, Center, School, or Institute: College of Science

Title of Contract, Award, or Gift: Portable, Non-Invasive, COVID-19 Detection and Analysis

Name of Granting or Contracting Agency/Entity: Worlds Enterprises, Inc.


Program Title: N/A


Current portable mass spectrometric technology has the ability to present data in real-time for the detection of Volatile Organic Compounds (VOCs), which are known to be generated by the body in the event that a healthy cell undergoes a viral infection. In the case of Influenza A, it’s been reported that the concentration of VOCs such as n-propyl acetate, propanal, and acetaldehyde are found to be rather high in a specimen’s breath. Hemagglutinin is the surface antigen expressed by influenza A, which will bind at the cell surface level to sialic acid (Figure 2). This will lead to the absorbance of the virus into the cell through receptor induced endocytosis process, which additionally includes those actions of clathrin, enzyme neuraminidase, and many other proteins present. The formation of n-propyl acetate substance, whether through endocytosis, protein binding, or even cell metabolism, mimics the properties of a viral infection. Its overall formation can be said to be a result of the interactions between the cell and the virus itself, since viruses lack their own metabolic process. These unique VOCs associated with a viral infection leads one to believe that COVID-19 will produce unique VOCs that can be used to determine the presence of COVID-19 viral infections in humans. The implementation of a portable mass spectrometer for the analysis and detection of VOCs correlated to viral infections would allow the enablement of non-invasive and destruction-free monitoring of viral infections, and potentially the biomarker characterization of said viral infections, which would facilitate the both the diagnosis and monitoring process.

Discussion: No discussion notes


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