Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

356  The University of Texas Rio Grande Valley  (84652)

Principal Investigator: Baker, Kelsey

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 14,495

Exceeds $250,000 (Is it flagged?): No

Start and End Dates: 1/1/21 - 8/31/21

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Molecular Science

Title of Contract, Award, or Gift: Improving Spinal Cord Injury Rehabilitation Interventions by Retraining the Brain

Name of Granting or Contracting Agency/Entity: U.S. Department of Defense
CFDA Link: DOD
12.420

Program Title: N/A
CFDA Linked: Military Medical Research and Development

Note:

The objective of this phase I/II multi-site randomized controlled, double-blinded clinical trial is to test the safety, feasibility, efficacy, and mechanisms of delivering tDCS with upper extremity rehabilitation in SCI. The specific aims of this study are: AIM 1: DETERMINE THE EFFECTIVENESS OF PAIRING TDCS WITH REHABILITATION. Hyp. 1: Patients receiving tDCS with rehabilitation will achieve greater gains in strength and dexterity, with reduction in activity limitations and participation restrictions, than those getting rehabilitation alone. Responders/non-responders will be identified based on baseline clinicodemographic characteristics, such as the level of injury, degree of incompleteness and time post-injury, etc. AIM 2: DETERMINE THE MECHANISMS OF PAIRING TDCS WITH REHABILITATION. Hyp. 2: Patients receiving tDCS with rehabilitation will exhibit larger gains in excitability of neural resources devoted to the weak triceps muscle (C7) and greater reductions in excitability of neural resources devoted to the spared biceps muscle (C5) compared with patients receiving rehabilitation alone. Patients receiving tDCS in rehabilitation will also exhibit larger gains in spinal excitability. Relationship between neural mechanisms and gains in strength and dexterity and functional abilities will be explored. AIM 3: DETERMINE THE SAFETY AND FEASIBILITY OF PAIRING TDCS WITH REHABILITATION. Hyp. 3: Patients receiving tDCS with rehabilitation will show no greater adverse effects or attrition or ability to correctly guess the group allocation than those receiving rehabilitation alone.

Discussion: No discussion notes

 

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