Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

345  The University of Texas Rio Grande Valley  (84641)

Principal Investigator: Ayati, Marzieh

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 139,130

Exceeds $250,000 (Is it flagged?): No

Start and End Dates: 7/15/19 - 3/31/22

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Computer Science

Title of Contract, Award, or Gift: Construction, Analysis, and Utilization of Co-Phosphorylation Networks to Characterize Cellular Signaling

Name of Granting or Contracting Agency/Entity: Case Western Reserve University

Program Title: Medical Library Assistance
CFDA Linked: Medical Library Assistance


This project aims to develop computational methods that will use phosphorylation data from diverse studies and different labs to elucidate the dynamics of the interactions and post-translational modifications among relevant proteins, phosphosites, kinases, and phosphatases. For this purpose, we propose to construct cophosphorylation networks by assessing the correlation (or statistical dependency in general terms) between pairs of phosphosites across a range of biological states, and develop algorithms and methods to analyze and utilize these networks to develop systems biology solutions to various problems. The proposed computational pipeline will introduce the notion of co-phosphorylation (co-P) networks to the scientific community, provide comprehensive methodologies for the construction, statistical assessment, and functional assessment of these networks, and validate their use in predictive tasks. Specifically, for experimental validation, we will use kinase inhibition studies in lung cancer cell lines and tissue samples from in vivo models of Alzheimer’s disease. The potential impact of this project is well beyond the results that will be generated by this project; utilization of co-P networks by a broad range of biomedical scientists will likely generate significant insights into the biology of cellular signaling and drive drug discovery for enhancing biomedical science.

Discussion: No discussion notes


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