Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

344  The University of Texas Rio Grande Valley  (84640)

Principal Investigator: Kim, Hyeongjun

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 10,350

Exceeds $250,000 (Is it flagged?): No

Start and End Dates: 4/1/21 - 3/31/22

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Physics and Astronomy

Title of Contract, Award, or Gift: How bacterial SMC complexes organize chromosomes

Name of Granting or Contracting Agency/Entity: Trustees of Indiana University / NIH

Program Title: Biomedical Research and Research Training
CFDA Linked: Biomedical Research and Research Training


Dr. Xindan Wang, the PI of this NIH R01 grant proposal, will utilize various in vivo assays such as Hi-C, ChIP, fluorescence-based live-cell imaging, and genetic approaches. As her collaborator, Dr. Kim’s work will complement her proposed research by focusing on fluorescence-based in vitro single-molecule experiments. More specifically, he will observe how fluorescently-labeled individual Bacillus subtilis SMC and XerD proteins interact with each other on doubly tethered DNAs, and extract underlying mechanistic working mechanisms. Those biophysical in vitro observations will provide new perspectives and lead to synergetic effects on what Dr. Wang finds from her in vivo experiments. Due to the nature of the research plan that requires multiple approaches with different angles, Dr. Kim’s findings from his single-molecule assays will be fully shared with Dr. Wang’s research group. Further, he will routinely discuss the results and subsequent research directions with Dr. Wang.

Discussion: No discussion notes


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