Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

343  The University of Texas Rio Grande Valley  (84639)

Principal Investigator: Maestre, Gladys

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 25,000

Exceeds $250,000 (Is it flagged?): No

Start and End Dates: 4/1/21 - 4/1/22

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Neuroscience

Title of Contract, Award, or Gift: To identify novel genetic variation underlying dementia in 3 large Hispanic families and to explore the biology of the novel variants identified in these families

Name of Granting or Contracting Agency/Entity: UT Health San Antonio


Program Title: N/A


Drs. Gladys Elena Maestre and John Blangero are requesting $25,000.00 for a project manager and for costs associated with detailed phenotyping in one large family from the San Antonio Family Heart Study with a genetically unidentified ADRD dementia, identified through AG058464 03S1 and who have whole genome sequencing and multiomic data through the Transomics in Precision Medicine (TOPMed) initiative. Dr. Maestre will hire and oversee a project coordinator at UTRGV ($10,000 for 20% of this person's time) and collaborate with Dr. Seshadri on generating and evaluating clinical and biomarker (neurological and cognitive, blood, CSF/PET biomarkers) data. We request $10,000 towards detailed phenotypic assessment of members of this extended family.

Discussion: No discussion notes


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