Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

311  The University of Texas Rio Grande Valley  (84607)

Principal Investigator: Roy, Upal

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 3,331,589

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: 7/16/20 - 6/30/25

Restricted Research: YES

Academic Discipline: N/A

Department, Center, School, or Institute: Health & Biomedical Sciences

Title of Contract, Award, or Gift: A targeted anti-HIV drug delivery to the GALT

Name of Granting or Contracting Agency/Entity: National Institutes of Health (NIH)

Program Title: Sustained Release of Antivirals for Treatment or Prevention of HIV (SRATP) (R01 Clinical Trial Not Allowed)
CFDA Linked: Allergy, Immunology and Transplantation Research


In this grant, I would like to propose the targeted nanomedicine based sustained drug release approach to treating HIV-1 infection in the GALT. GALT plays an important role during early and late HIV infection. Moreover, it also serves as an HIV reservoir. It has been observed that GALT is majorly destroyed by the initial phase of HIV infection and did not recover even in anti-retroviral drug-treated patients. As GALT host most of the immune cells of the human, it is very important to treat GALT in order to restore the immune system to combat the disease. In this regard, targeted treatment towards GALT is a priority with respect to HIV therapy. Here, we propose to develop a nanodrug that is targeted to the Microfold cells (M-Cell) of GALT. Our initial publication showed that M-cells are efficient to transport anti-HIV nanodrug to the GALT. The overall goal of this proposal is to investigate the transcytosis property of M-cell with respect to three anti-HIV drug delivery across the lumen to the gut lymphatic tissue. At the end of our study, we will have a nanoformulation that will efficiently transport and deliver these drugs to GALT more efficiently for an extended period of time. SAMs 1.1.1

Discussion: No discussion notes


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