Restricted Research - Award List, Note/Discussion Page

Fiscal Year: 2021

138  University of North Texas  (84434)

Principal Investigator: Shah,Jyoti

Total Amount of Contract, Award, or Gift (Annual before 2011): $ 493,867

Exceeds $250,000 (Is it flagged?): Yes

Start and End Dates: - 11/14/23

Restricted Research: YES

Academic Discipline: Biological Sciences

Department, Center, School, or Institute: College of Science

Title of Contract, Award, or Gift: Facilitation of Fusarium graminearum invasiveness by plant 9-lipoxygenase

Name of Granting or Contracting Agency/Entity: U.S. Department of Agriculture

CFDA: 10.310

Program Title: N/A


1.1.1 (SAM); IBC Protocol #2020-14; Fusarium graminearum is the principal causal agent of Fusarium head blight (FHB), a devastating disease of wheat. The development of FHB-resistant wheat has been hampered by limited understanding of mechanisms underlying plant resistance and susceptibility to this fungus. Recent studies indicate that while salicylic acid signaling has an important role in wheat defense against this fungus, disease is promoted by a wheat 9-lipoxygenase and lipases secreted by the fungus, thus implicating lipids in susceptibility to FHB. The central hypothesis to be tested is that a 9-lipoxygenase-derived oxylipin(s) facilitates F. graminearum infection of wheat by suppressing the activation of defenses and/or providing a factor required for fungal growth and/or pathogenicity. A combination of genetic, molecular, biochemical and lipidomic approaches will be utilized to study the role of lipids and lipid-metabolizing enzymes in promoting F. graminearum infection in wheat. The specific objectives are to: (1) Characterize the mechanism underlying the resistance to Fusarium head blight conferred by knockdown of 9-lipoxygenase in wheat, and (2) Identify the 9-LOX (Lpx3) substrate(s) and product(s) that are relevant to wheat-F. graminearum interaction. These objectives, which are relevant to AFRI’s Plant Health and Production and Plant Products’ program area priority of Understanding Plant-Associated Microorganisms and Plant-Microbe Interactions, will fill important gaps in the understanding of mechanisms underlying interaction between an agriculturally important plant and pathogen, and facilitate future development of novel strategies for controlling this damaging disease. The fungal and wheat lipidome data resulting from this study will be useful to the broader community.

Discussion: No discussion notes


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